Shear-induced capping of l-selectin on the neutrophil surface during centrifugation
نویسندگان
چکیده
منابع مشابه
Kinetics of beta2-integrin and L-selectin bonding during neutrophil aggregation in shear flow.
Activated neutrophils aggregate in a shear field via bonding of L-selectin to P-selectin glycoprotein ligand-1 (PSGL-1) followed by a more stable bonding of LFA-1 (CD11a/CD18) to intercellular adhesion molecule 3 (ICAM-3) and Mac-1 (CD11b/CD18) to an unknown counter receptor. Assuming that the Mac-1 counter receptor is ICAM-3-like in strength and number, rate processes were deconvoluted from ne...
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Shear-dependent capping of L-selectin and P-selectin glycoprotein ligand 1 by E-selectin signals activation of high-avidity beta2-integrin on neutrophils.
Two adhesive events critical to efficient recruitment of neutrophils at vascular sites of inflammation are up-regulation of endothelial selectins that bind sialyl Lewis(x) ligands and activation of beta(2)-integrins that support neutrophil arrest by binding ICAM-1. We have previously reported that neutrophils rolling on E-selectin are sufficient for signaling cell arrest through beta(2)-integri...
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ژورنال
عنوان ژورنال: Journal of Immunological Methods
سال: 2007
ISSN: 0022-1759
DOI: 10.1016/j.jim.2007.08.011